"We develop novel scientific devices and methods for applications in biomolecular physics, biological chemistry, and molecular medicine. To this end, we currently focus on using DNA as a programmable construction material for building nanometer-scale scientific devices with atomically precise features. We also customize proteins and create and study hybrid DNA-protein complexes."
"We develop novel imaging methods for biological and biomedical applications by combining tools from structural and dynamic DNA nanotechnology with single-molecule fluorescence methods, especially targeted towards the development and application of super-resolution microscopy techniques. Using the unique programmability of DNA molecules, we are working on extending DNA-PAINT to eventually being able to perform highly multiplexed (hundreds of targets), ultra-resolution (<5 nm), and quantitative (integer counting of molecules) imaging of biomolecules (i.e. proteins and nucleic acids) and their interactions. Our vision is to unravel the location and interplay of a multitude of genes, RNAs, and proteins in a truly quantitative fashion with highest spatial resolution in single cells."
"We are interested in molecular self-assembly processes in general and particularly in the engineering of functional DNA devices using the DNA origami method. With the goal to create and study nanophotonic effects, we focus on the combination of self-assembled DNA nanostructures with other nanocomponents, such as nanoparticles or fluorophores. The design of functional DNA hybrid materials and its characterization may also help us to understand the mechanical and chemical interactions across multiple levels of organization between the different molecular components in living cells and tissues."
"Our goal is the realization of self-organizing molecular systems that are able to respond to their environment, compute, move, take action. On the long term, we envision autonomous systems that are reconfigurable, that can evolve, develop, or even learn."
"With our background in single-molecule biophysics and superresolution microscopy, we develop DNA hybrid devices for applications in molecular biophysics and biosensing. Applications include DNA nanorulers for superresolution microscopy, plasmonic fluorescence amplifiers for molecular diagnostics, nanoadapters and DNA origami force clamps."